Because the discovery of antibiotics like penicillin the demand of manuka honey reduced a lot. The therapeutic use of honey shrunk substantially because of the popular use of antibiotics throughout that time. However even a long time before these formulations were developed ancients thought in the therapeutic use of manuka honey. Actually, it was a significant element of the wonder program of queens and princesses in the olden times. Nowadays with the enormous development of antibacterial resistant bacteria the recognition of manuka honey is again increasing.